Publications

2022

Kim S, Li C, Farese RV Jr, Walther TC, Voth GA. Key Factors Governing Initial Stages of Lipid Droplet Formation. J Phys Chem B. 2022 Jan 6. doi: 10.1021/acs.jpcb.1c09683. Epub ahead of print. PMID: 34990551.

 

2021

Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV Jr, Lippincott-Schwartz J, Mellman I, Solimena M, Hess HF. An open-access volume electron microscopy atlas of whole cells and tissues.Nature. 2021 Nov;599(7883):147-151. doi: 10.1038/s41586-021-03992-4. Epub 2021 Oct 6.PMID: 34616045

Olarte MJ, Swanson JMJ, Walther TC, Farese RV Jr. The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting. Trends Biochem Sci. 2021 Sep 25:S0968-0004(21)00187-0. doi: 10.1016/j.tibs.2021.08.007. .PMID: 34583871 Review.

Kumar S, Chitraju C, Farese RV Jr, Walther TC, Burd CG. Conditional targeting of phosphatidylserine decarboxylase to lipid droplets. Biol Open. 2021 Mar 3;10(3):bio058516. doi: 10.1242/bio.058516. PMID: 33593792.

Farese RV Jr, Walther TC. The power of two: lessons from a scientific partnership. J Clin Invest. 2021 Jan 19;131(2):e145966. doi: 10.1172/JCI145966. PMID: 33463550; PMCID: PMC7810469.

 

2020

Christiano R, Arlt H, Kabatnik S, Mejhert N, Lai ZW, Farese RV Jr, Walther TC. A Systematic Protein Turnover Map for Decoding Protein Degradation. Cell Rep. 2020 Nov 10;33(6):108378. doi: 10.1016/j.celrep.2020.108378.PMID: 33176155 

Chitraju C, Fischer AW, Farese RV Jr, Walther TC. Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.Cell Rep. 2020 Nov 3;33(5):108348. doi: 10.1016/j.celrep.2020.108348.PMID: 3314746

Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC, Farese RV. FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis. J Cell Biol. 2020 Oct 5;219(10). doi: 10.1083/jcb.202006111. PubMed PMID: 32915949.

Olarte MJ, Kim S, Sharp ME, Swanson JMJ, Farese RV Jr, Walther TC. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Dev Cell. 2020 Aug 24;54(4):471-487.e7. doi: 10.1016/j.devcel.2020.07.001. Epub 2020 Jul 29. PubMed PMID: 32730754; NIHMSID:NIHMS1617288.

Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.Nature. 2020 May;581(7808):323-328. doi: 10.1038/s41586-020-2289-6. Epub 2020 May 13. PMID: 32433611

Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV Jr, Walther TC. Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration. Natl Acad Sci U S A. 2020 May 12;117(19):10565-10574. doi: 10.1073/pnas.1913956117. Epub 2020 Apr 28. PMID: 32345721


Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV Jr, Walther TC. Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. Mol Cell. 2020 Mar 19;77(6):1251-1264.e9. doi: 10.1016/j.molcel.2020.01.014. Epub 2020 Feb 4. PubMed PMID: 32023484.

2019

 

Chung J, Wu X, Lambert TJ, Lai ZW, Walther TC, Farese RV Jr.LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Dev Cell. 2019 Dec 2;51(5):551-563.e7. doi: 10.1016/j.devcel.2019.10.006. Epub 2019 Nov 7.PMID: 31708432

Walther TC, Farese RV Jr. Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics. Dev Cell. 2019 Sep 9;50(5):530-532. doi: 10.1016/j.devcel.2019.08.009. PMID: 31505174

Vejnar CE, Abdel Messih M, Takacs CM, Yartseva V, Oikonomou P, Christiano R, Stoeckius M, Lau S, Lee MT, Beaudoin JD, Musaev D, Darwich-Codore H, Walther TC, Tavazoie S, Cifuentes D, Giraldez AJ. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in ze Genome Res. 2019 Jul;29(7):1100-1114. doi: 10.1101/gr.245159.118. Epub 2019 Jun 21. PMID: 31227602

Luscher A, Fröhlich F, Barisch C, Littlewood C, Metcalfe J, Leuba F, Palma A, Pirruccello M, Cesareni G, Stagi M, Walther TC, Soldati T, De Camilli P, Swan LE. Lowe syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum Mol Biol Cell. 2019 Aug 1;30(17):2268-2282. doi: 10.1091/mbc.E18-08-0510. Epub 2019 Jun 19. PMID: 31216233

Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV Jr, Walther TC. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice. Hepatology. 2019 May 13. doi: 10.1002/hep.30765. [Epub ahead of print] PMID: 31081165

Chitraju C, Walther TC, Farese RV Jr. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. J Lipid Res. 2019 Jun;60(6):1112-1120. doi: 10.1194/jlr.M093112. Epub 2019 Apr 1. PMID: 30936184

Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV Jr. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.  Mol Cell. 2019 Apr 4;74(1):32-44.e8. doi: 10.1016/j.molcel.2019.01.036. Epub 2019 Mar 4. PMID: 30846318

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. PMID: 30527540

2018

Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV Jr, Walther TC. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. Cell Biol. 2018 Dec 3;217(12):4080-4091. doi: 10.1083/jcb.201809067. Epub 2018 Oct 16. PMID: 30327422

Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV Jr. Progranulin in the hematopoietic compartment protects mice from atherosclerosis.   Atherosclerosis. 2018 Aug 30;277:145-154. doi: 10.1016/j.atherosclerosis.2018.08.042. [Epub ahead of print] PMID: 30212683

Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV Jr, Walther TC. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Mol Biol Cell. 2018 Aug 15;29(17):2045-2054. doi: 10.1091/mbc.E18-05-0282. Epub 2018 Jun 27. PMID: 29949452

Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV Jr. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12): E2849-E2858. doi: 10.1073/pnas.1722344115. Epub 2018 Mar 6. PMID: 29511098

Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV Jr. Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity.V. Mol Cell Proteomics. 2018 May;17(5):836-849. doi: 10.1074/mcp.RA117.000560. Epub 2018 Feb 5.PMID: 29414761

Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV Jr., Walther TC. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. Dev Cell. 2018 Jan 8;44(1):73-86.e4. doi: 10.1016/j.devcel.2017.12.011. Epub 2018 Jan 8. PubMed PMID: 29316443

Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV Jr., Cravatt BF. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2018 Feb 6;57(5):827-838. doi: 10.1021/acs.biochem.7b01028. Epub 2017 Dec 26.
PMID: 29278326

Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. Elife. 2018 Dec 24;7. pii: e43036. doi: 10.7554/eLife.43036. PMID: 30582518

Krahmer N, Najafi B, Schueder F, Quagliarini F, Steger M, Seitz S, Kasper R, Salinas F, Cox J, Uhlenhaut NH, Walther TC, Jungmann R, Zeigerer A, Borner GHH, Mann M. Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis. Dev Cell. 2018 Oct 22;47(2):205-221.e7. doi: 10.1016/j.devcel.2018.09.017. PMID: 30352176

Eikrem Ø, Walther TC, Flatberg A, Beisvag V, Strauss P, Farstad M, Beisland C, Koch E, Mueller TF, Marti HP. Fine needle aspirates of kidneys: a promising tool for RNA sequencing in native and transplanted kidneys. BMC Nephrol. 2018 Sep 5;19(1):221. doi: 10.1186/s12882-018-1012-4. PMID: 30185151

Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J. Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop. Circulation. 2018 Jul 17;138(3):305-315.doi:10.1161/CIRCULATIONAHA.118.033704. Review. PMID: 30012703

2017

Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV Jr, Cravatt BF.  Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2017 Dec 26. doi: 10.1021/acs.biochem.7b01028. PubMed PMID: 29278326

Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV Jr, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL.  An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations. Alzheimers Dement (N Y). 2017 Sep 12;3(4):507-512. doi: 10.1016/j.trci.2017.08.002. eCollection 2017 Nov. PubMed PMID: 29124108

Walther TC, Chung J, Farese RV Jr.  Lipid Droplet Biogenesis. Annu Rev Cell Dev Biol. 2017 Oct 6;33:491-510. doi: 10.1146/annurev-cellbio-100616-060608. Epub 2017 Aug 9. PubMed PMID: 28793795

Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV Jr. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metab. 2017 Aug 1;26(2):407-418.e3. doi: 10.1016/j.cmet.2017.07.012. PubMed PMID:28768178

Christiano R, Kolev NG, Shi H, Ullu E, Walther TC, Tschudi C. The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion. Mol Microbiol. 2017 Oct;106(1):74-92. doi: 10.1111/mmi.13754. Epub 2017 Aug 4. PubMed PMID: 28742275

Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV Jr, Gan L. Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc Natl Acad Sci U S A. 2017 May 9;114(19):5029-5034. doi: 10.1073/pnas.1700477114. Epub 2017 Apr 24. PubMed PMID: 28438992

Gluchowski NL, Becuwe M, Walther TC, Farese RV Jr. Lipid droplets and liver disease: from basic biology to clinical implications. Nat Rev Gastroenterol Hepatol. 2017 Jun;14(6):343-355. doi: 10.1038/nrgastro.2017.32. Epub 2017 Apr 21. Review. PubMed PMID: 28428634

Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV Jr. Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. J Lipid Res. 2017 Jun;58(6):1230-1237. doi: 10.1194/jlr.P075119. Epub 2017 Apr 3. PubMed PMID: 28373485

Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV Jr, Walther TC. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J Lipid Res. 2017 Jan;58(1):226-235. doi: 10.1194/jlr.M072538. Epub 2016 Nov 11. PubMed PMID: 27836991

 

2016

Fröhlich F, Olson DK, Christiano R, Farese RV Jr, Walther TC. Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 2016 Nov;16(21):2759-2763. doi: 10.1002/pmic.201600269. PubMed PMID: 27717283.

Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat Cell Biol. 2016 Jan;18(1):132-8. doi: 10.1038/ncb3271. PubMed PMID: 26571211; PubMed Central PMCID: PMC4689616.

Olson DK, Fröhlich F, Farese RV Jr, Walther TC. Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta. 2016 Aug;1861(8 Pt B):784-92. doi: 10.1016/j.bbalip.2015.12.021. Review. PubMed PMID: 26747648; PubMed Central PMCID: PMC4907851.

Kory N, Farese RV Jr, Walther TC. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. Trends Cell Biol. 2016 Jul;26(7):535-46. doi: 10.1016/j.tcb.2016.02.007. Review. PubMed PMID: 26995697; PubMed Central PMCID: PMC4976449.

Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26;5. pii: e16582. doi: 10.7554/eLife.16582. PubMed PMID: 27564575; PubMed Central PMCID: PMC5035145.

Farese RV Jr, Walther TC. Lipid droplets go nuclear. J Cell Biol. 2016 Jan 4;212(1):7-8. doi: 10.1083/jcb.201512056. PubMed PMID: 26728852; PubMed Central PMCID: PMC4700486.

Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV Jr, Paz JT, Barres BA, Huang EJ. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 5;165(4):921-35. doi: 10.1016/j.cell.2016.04.001. PubMed PMID: 27114033; PubMed Central PMCID: PMC4860138.

Agarwal AK, Tunison K, Dalal JS, Yen CL, Farese RV Jr, Horton JD, Garg A. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016 Apr;57(4):616-30. doi: 10.1194/jlr.M065896. PubMed PMID: 26880786; PubMed Central PMCID: PMC4808770.

2015

Frohlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC. The GARP complex is required for cellular sphingolipid homeostasis. Elife. 2015;4. doi: 10.7554/eLife.08712. PubMed PMID: 26357016; PMCID: PMC4600884.

Kory N, Thiam AR, Farese RV, Jr., Walther TC. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell. 2015;34(3):351-63. doi:10.1016/j.devcel.2015.06.007. PubMed PMID: 26212136; PMCID: PMC4536137.

Shibuya A, Margulis N, Christiano R, Walther TC, Barlowe C. The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins. J Cell Biol. 2015;208(2):197-209. doi: 10.1083/jcb.201408024. PubMed PMID: 25583996; PMCID: PMC4298680.

Siragusa M, Frohlich F, Park EJ, Schleicher M, Walther TC, Sessa WC. Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation. Sci Signal. 2015;8(390):ra81. doi: 10.1126/scisignal.aaa2819. PubMed PMID: 26286023.

Olson DK, Frohlich F, Christiano R, Hannibal-Bach HK, Ejsing CS, Walther TC. Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids. J Biol Chem. 2015;290(7):4238-47. doi: 10.1074/jbc.M114.629279. PubMed PMID: 25519905; PMCID: PMC4326832.

2014

Bazzini AA, Johnstone TG, Christiano R, Mackowiak SD, Obermayer B, Fleming ES, Vejnar CE, Lee MT, Rajewsky N, Walther TC, Giraldez AJ. Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation. EMBO J. 2014;33(9):981-93. doi: 10.1002/embj.201488411. PubMed PMID: 24705786; PMCID: PMC4193932.

Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Jr., Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014;289(52):35770-80. doi: 10.1074/jbc.M114.587816. PubMed PMID: 25381252; PMCID: PMC4276846.

Christiano R, Nagaraj N, Frohlich F, Walther TC. Global proteome turnover analyses of the Yeasts S. cerevisiae and S. pombe. Cell Rep. 2014;9(5):1959-65. doi: 10.1016/j.celrep.2014.10.065. PubMed PMID: 25466257; PMCID: PMC4526151.

Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV, Jr. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J Lipid Res. 2014;55(7):1465-77. doi: 10.1194/jlr.M050229. PubMed PMID: 24868093; PMCID: PMC4076087.

Frohlich F, Christiano R, Olson DK, Alcazar-Roman A, DeCamilli P, Walther TC. A role for eisosomes in maintenance of plasma membrane phosphoinositide levels. Mol Biol Cell. 2014;25(18):2797-806. doi: 10.1091/mbc.E13-11-0639. PubMed PMID: 25057013; PMCID: PMC4161514.

Fu D, Yu Y, Folick A, Currie E, Farese RV, Jr., Tsai TH, Xie XS, Wang MC. In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy. J Am Chem Soc. 2014;136(24):8820-8. doi: 10.1021/ja504199s. PubMed PMID: 24869754; PMCID: PMC4073829.

Harrison MS, Hung CS, Liu TT, Christiano R, Walther TC, Burd CG. A mechanism for retromer endosomal coat complex assembly with cargo. Proc Natl Acad Sci U S A. 2014;111(1):267-72. doi: 10.1073/pnas.1316482111. PubMed PMID: 24344282; PMCID: PMC3890810.

Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV, Jr., Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ. Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure. J Biol Chem. 2014;289(43):29881-91. doi: 10.1074/jbc.M114.601864. PubMed PMID: 25157099; PMCID: PMC4207999.

Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Jr., Gan L. Progranulin protects against amyloid beta deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014;20(10):1157-64. doi: 10.1038/nm.3672. PubMed PMID: 25261995; PMCID: PMC4196723.

Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV, Jr., Seeley RJ, Sandoval DA. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014;307(11):E1065-72. doi: 10.1152/ajpendo.00376.2014. PubMed PMID: 25315695; PMCID: PMC4254982.

Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB. Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease. Proc Natl Acad Sci U S A. 2014;111(24):8901-6. doi: 10.1073/pnas.1408523111. PubMed PMID: 24889630; PMCID: PMC4066527.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Jr., Green A, Gan L. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014;211(10):1937-45. doi: 10.1084/jem.20140214. PubMed PMID: 25155018; PMCID: PMC4172214.

Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Jr., Walther TC. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 2014;3:e01607. doi: 10.7554/eLife.01607. PubMed PMID: 24497546; PMCID: PMC3913038.

Wilfling F, Haas JT, Walther TC, Farese RV, Jr. Lipid droplet biogenesis. Curr Opin Cell Biol. 2014;29:39-45. doi: 10.1016/j.ceb.2014.03.008. PubMed PMID: 24736091; PMCID: PMC4526149.

2013

Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Jr., Ott M. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013;288(14):9915-23. doi: 10.1074/jbc.M112.434910. PubMed PMID: 23420847; PMCID: PMC3617291.

Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV, Jr., Kukar T, Tansey MG. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci. 2013;33(21):9202-13. doi: 10.1523/JNEUROSCI.5336-12.2013. PubMed PMID: 23699531; PMCID: PMC3707136.

Currie E, Schulze A, Zechner R, Walther TC, Farese RV, Jr. Cellular fatty acid metabolism and cancer. Cell Metab. 2013;18(2):153-61. doi: 10.1016/j.cmet.2013.05.017. PubMed PMID: 23791484; PMCID: PMC3742569.

Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB, Farese RV, Jr., Roberson ED. Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. J Neurosci. 2013;33(12):5352-61. doi: 10.1523/JNEUROSCI.6103-11.2013. PubMed PMID: 23516300; PMCID: PMC3740510.

Frohlich F, Christiano R, Walther TC. Native SILAC: metabolic labeling of proteins in prototroph microorganisms based on lysine synthesis regulation. Mol Cell Proteomics. 2013;12(7):1995-2005. doi: 10.1074/mcp.M112.025742. PubMed PMID: 23592334; PMCID: PMC3708181.

Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Jr., Blackstone C, Guo Y, Mak HY. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013;3(5):1465-75. doi: 10.1016/j.celrep.2013.04.015. PubMed PMID: 23684613; PMCID: PMC3742324.

Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Jr., Walther TC. Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics. 2013;12(5):1115-26. doi: 10.1074/mcp.M112.020230. PubMed PMID: 23319140; PMCID: PMC3650325.
Krahmer N, Farese RV, Jr., Walther TC. Balancing the fat: lipid droplets and human disease. EMBO Mol Med. 2013;5(7):905-15. doi: 10.1002/emmm.201100671. PubMed PMID: 23740690; PMCID: PMC3721468.

Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV, Jr. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). J Biol Chem. 2013;288(12):8627-35. doi: 10.1074/jbc.M112.441949. PubMed PMID: 23364791; PMCID: PMC3605681.
Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV, Jr. Progranulin: at the interface of neurodegenerative and metabolic diseases. Trends Endocrinol Metab. 2013;24(12):597-606. doi: 10.1016/j.tem.2013.08.003. PubMed PMID: 24035620; PMCID: PMC3842380.

Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, Jr., de Cabo R, Ulrich S, Akassoglou K, Verdin E. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013;339(6116):211-4. doi: 10.1126/science.1227166. PubMed PMID: 23223453; PMCID: PMC3735349.

Thiam AR, Antonny B, Wang J, Delacotte J, Wilfling F, Walther TC, Beck R, Rothman JE, Pincet F. COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci U S A. 2013;110(33):13244-9. doi: 10.1073/pnas.1307685110. PubMed PMID: 23901109; PMCID: PMC3746913.

Thiam AR, Farese RV, Jr., Walther TC. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol. 2013;14(12):775-86. doi: 10.1038/nrm3699. PubMed PMID: 24220094; PMCID: PMC4526153.

Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Frohlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, Jr., Walther TC. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013;24(4):384-99. doi: 10.1016/j.devcel.2013.01.013. PubMed PMID: 23415954; PMCID: PMC3727400.

Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Jr., Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013;8(10):e76055. doi: 10.1371/journal.pone.0076055. PubMed PMID: 24143176; PMCID: PMC3797144.