2013

Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Jr., Ott M. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. J Biol Chem. 2013;288(14):9915-23. doi: 10.1074/jbc.M112.434910. PubMed PMID: 23420847; PMCID: PMC3617291.

Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV, Jr., Kukar T, Tansey MG. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. J Neurosci. 2013;33(21):9202-13. doi: 10.1523/JNEUROSCI.5336-12.2013. PubMed PMID: 23699531; PMCID: PMC3707136.

Currie E, Schulze A, Zechner R, Walther TC, Farese RV, Jr. Cellular fatty acid metabolism and cancer. Cell Metab. 2013;18(2):153-61. doi: 10.1016/j.cmet.2013.05.017. PubMed PMID: 23791484; PMCID: PMC3742569.

Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB, Farese RV, Jr., Roberson ED. Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. J Neurosci. 2013;33(12):5352-61. doi: 10.1523/JNEUROSCI.6103-11.2013. PubMed PMID: 23516300; PMCID: PMC3740510.

Frohlich F, Christiano R, Walther TC. Native SILAC: metabolic labeling of proteins in prototroph microorganisms based on lysine synthesis regulation. Mol Cell Proteomics. 2013;12(7):1995-2005. doi: 10.1074/mcp.M112.025742. PubMed PMID: 23592334; PMCID: PMC3708181.

Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Jr., Blackstone C, Guo Y, Mak HY. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013;3(5):1465-75. doi: 10.1016/j.celrep.2013.04.015. PubMed PMID: 23684613; PMCID: PMC3742324.

Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Jr., Walther TC. Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics. 2013;12(5):1115-26. doi: 10.1074/mcp.M112.020230. PubMed PMID: 23319140; PMCID: PMC3650325.
Krahmer N, Farese RV, Jr., Walther TC. Balancing the fat: lipid droplets and human disease. EMBO Mol Med. 2013;5(7):905-15. doi: 10.1002/emmm.201100671. PubMed PMID: 23740690; PMCID: PMC3721468.

Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV, Jr. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). J Biol Chem. 2013;288(12):8627-35. doi: 10.1074/jbc.M112.441949. PubMed PMID: 23364791; PMCID: PMC3605681.
Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV, Jr. Progranulin: at the interface of neurodegenerative and metabolic diseases. Trends Endocrinol Metab. 2013;24(12):597-606. doi: 10.1016/j.tem.2013.08.003. PubMed PMID: 24035620; PMCID: PMC3842380.

Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, Jr., de Cabo R, Ulrich S, Akassoglou K, Verdin E. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013;339(6116):211-4. doi: 10.1126/science.1227166. PubMed PMID: 23223453; PMCID: PMC3735349.

Thiam AR, Antonny B, Wang J, Delacotte J, Wilfling F, Walther TC, Beck R, Rothman JE, Pincet F. COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci U S A. 2013;110(33):13244-9. doi: 10.1073/pnas.1307685110. PubMed PMID: 23901109; PMCID: PMC3746913.

Thiam AR, Farese RV, Jr., Walther TC. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol. 2013;14(12):775-86. doi: 10.1038/nrm3699. PubMed PMID: 24220094; PMCID: PMC4526153.

Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Frohlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, Jr., Walther TC. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013;24(4):384-99. doi: 10.1016/j.devcel.2013.01.013. PubMed PMID: 23415954; PMCID: PMC3727400.

Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Jr., Moore MJ, Shaw CE, Gao FB. Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013;8(10):e76055. doi: 10.1371/journal.pone.0076055. PubMed PMID: 24143176; PMCID: PMC3797144.