2014

Bazzini AA, Johnstone TG, Christiano R, Mackowiak SD, Obermayer B, Fleming ES, Vejnar CE, Lee MT, Rajewsky N, Walther TC, Giraldez AJ. Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation. EMBO J. 2014;33(9):981-93. doi: 10.1002/embj.201488411. PubMed PMID: 24705786; PMCID: PMC4193932.

Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Jr., Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets. J Biol Chem. 2014;289(52):35770-80. doi: 10.1074/jbc.M114.587816. PubMed PMID: 25381252; PMCID: PMC4276846.

Christiano R, Nagaraj N, Frohlich F, Walther TC. Global proteome turnover analyses of the Yeasts S. cerevisiae and S. pombe. Cell Rep. 2014;9(5):1959-65. doi: 10.1016/j.celrep.2014.10.065. PubMed PMID: 25466257; PMCID: PMC4526151.

Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV, Jr. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. J Lipid Res. 2014;55(7):1465-77. doi: 10.1194/jlr.M050229. PubMed PMID: 24868093; PMCID: PMC4076087.

Frohlich F, Christiano R, Olson DK, Alcazar-Roman A, DeCamilli P, Walther TC. A role for eisosomes in maintenance of plasma membrane phosphoinositide levels. Mol Biol Cell. 2014;25(18):2797-806. doi: 10.1091/mbc.E13-11-0639. PubMed PMID: 25057013; PMCID: PMC4161514.

Fu D, Yu Y, Folick A, Currie E, Farese RV, Jr., Tsai TH, Xie XS, Wang MC. In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy. J Am Chem Soc. 2014;136(24):8820-8. doi: 10.1021/ja504199s. PubMed PMID: 24869754; PMCID: PMC4073829.

Harrison MS, Hung CS, Liu TT, Christiano R, Walther TC, Burd CG. A mechanism for retromer endosomal coat complex assembly with cargo. Proc Natl Acad Sci U S A. 2014;111(1):267-72. doi: 10.1073/pnas.1316482111. PubMed PMID: 24344282; PMCID: PMC3890810.

Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV, Jr., Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ. Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure. J Biol Chem. 2014;289(43):29881-91. doi: 10.1074/jbc.M114.601864. PubMed PMID: 25157099; PMCID: PMC4207999.

Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Jr., Gan L. Progranulin protects against amyloid beta deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014;20(10):1157-64. doi: 10.1038/nm.3672. PubMed PMID: 25261995; PMCID: PMC4196723.

Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV, Jr., Seeley RJ, Sandoval DA. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014;307(11):E1065-72. doi: 10.1152/ajpendo.00376.2014. PubMed PMID: 25315695; PMCID: PMC4254982.

Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB. Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease. Proc Natl Acad Sci U S A. 2014;111(24):8901-6. doi: 10.1073/pnas.1408523111. PubMed PMID: 24889630; PMCID: PMC4066527.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Jr., Green A, Gan L. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014;211(10):1937-45. doi: 10.1084/jem.20140214. PubMed PMID: 25155018; PMCID: PMC4172214.

Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Jr., Walther TC. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 2014;3:e01607. doi: 10.7554/eLife.01607. PubMed PMID: 24497546; PMCID: PMC3913038.

Wilfling F, Haas JT, Walther TC, Farese RV, Jr. Lipid droplet biogenesis. Curr Opin Cell Biol. 2014;29:39-45. doi: 10.1016/j.ceb.2014.03.008. PubMed PMID: 24736091; PMCID: PMC4526149.